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	Provedor de dados BJMBR (3) Autor Aoki,M.S. (3) Miyabara,E.H. (2) Moriscot,A.S. (2) Brum,P.C. (1) Bueno Junior,C. (1) Oliveira,E.M. (1) Pereira,M.G. (1) Roschel,H. (1) Salvini,T.F. (1) Soares,A.G. (1) Souza,E.O.de (1) Tricoli,V. (1) Urginowitsch,C. (1) Mais... Palavra-chave Calcineurin (2) AMPK (1) Cell signaling (1) Concurrent training (1) Cyclosporin A (1) Cyclosporin-A (1) Fast and slow twitch muscles (1) Hypertrophy (1) Immobilization (1) Recovery (1) Regeneration (1) Skeletal muscle (1) Strength exercise (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (1) Ano 2013 (1) 2006 (1) 2005 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Cyclosporin A preferentially attenuates skeletal slow-twitch muscle regeneration BJMBR Miyabara,E.H.; Aoki,M.S.; Moriscot,A.S.. Calcineurin, a Ca2+/calmodulin-dependent phosphatase, is associated with muscle regeneration via NFATc1/GATA2-dependent pathways. However, it is not clear whether calcineurin preferentially affects the regeneration of slow- or fast-twitch muscles. We investigated the effect of a calcineurin inhibitor, cyclosporin A (CsA), on the morphology and fiber diameter of regenerating slow- and fast-twitch muscles. Adult Wistar rats (259.5 ± 9 g) maintained under standard conditions were treated with CsA (20 mg/kg body weight, ip) for 5 days, submitted to cryolesion of soleus and tibialis anterior (TA) muscles on the 6th day, and then treated with CsA for an additional 21 days. The muscles were removed, weighed, frozen, and stored in liquid nitrogen. Cryolesion did... Tipo: Info:eu-repo/semantics/other Palavras-chave: Calcineurin; Cyclosporin A; Regeneration; Fast and slow twitch muscles. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400009 Cyclosporin-A does not affect skeletal muscle mass during disuse and recovery BJMBR Aoki,M.S.; Miyabara,E.H.; Soares,A.G.; Salvini,T.F.; Moriscot,A.S.. Cyclosporin-A (CsA) is an immunosuppressive drug that acts as an inhibitor of calcineurin, a calcium phosphatase that has been suggested to play a role in skeletal muscle hypertrophy. The aim of the present study was to determine the effect of CsA administration (25 mg kg-1 day-1) on skeletal muscle mass and phenotype during disuse and recovery. Male Wistar rats received vehicle (N = 8) or CsA (N = 8) during hind limb immobilization (N = 8) and recovery (N = 8). Muscle weight (dry/wet) and cross-sectional area were evaluated to verify the effect of CsA treatment on muscle mass. Muscle phenotype was assessed by histochemistry of myosin ATPase. CsA administration during immobilization and recovery did not change muscle/body weight ratio in the soleus (SOL)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Calcineurin; Immobilization; Recovery; Skeletal muscle; Hypertrophy; Cyclosporin-A. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200011 The acute effects of strength, endurance and concurrent exercises on the Akt/mTOR/p70S6K1 and AMPK signaling pathway responses in rat skeletal muscle BJMBR Souza,E.O.de; Tricoli,V.; Bueno Junior,C.; Pereira,M.G.; Brum,P.C.; Oliveira,E.M.; Roschel,H.; Aoki,M.S.; Urginowitsch,C.. The activation of competing intracellular pathways has been proposed to explain the reduced training adaptations after concurrent strength and endurance exercises (CE). The present study investigated the acute effects of CE, strength exercises (SE), and endurance exercises (EE) on phosphorylated/total ratios of selected AMPK and Akt/mTOR/p70S6K1 pathway proteins in rats. Six animals per exercise group were killed immediately (0 h) and 2 h after each exercise mode. In addition, 6 animals in a non-exercised condition (NE) were killed on the same day and under the same conditions. The levels of AMPK, phospho-Thr172AMPK (p-AMPK), Akt, phospho-Ser473Akt (p-Akt), p70S6K1, phospho-Thr389-p70S6K1(p-p70S6K1), mTOR, phospho-Ser2448mTOR (p-mTOR), and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Strength exercise; Concurrent training; Cell signaling; AMPK. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400343 Registros recuperados: 3 Primeira ... 1 ... Última

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